Advances in Leukemia Research and Treatment

Research Article Pages 39-46

Comparison of Multiparameter Flow Cytometry and ClonoSEQ Studies for Precursor B-Lymphoblastic Leukemia Minimal Residual Disease Detection on Bone Marrow Samples

Authors: Nouran Momen, Joseph Tario, Kai Fu and You-Wen Qian

Abstract: Minimal residual disease (MRD) detection for precursor B-lymphoblastic leukemia (B-ALL) has become standard of care. We retrospectively compared MRD evaluation using COG Multiparameteric flow cytometry (MFC) and ClonoSEQ technique to assess the test characteristics. Seventy-four bone marrow samples from thirty-one B-ALL patients were collected at Roswell Park Cancer Center (RPCC) between January 2021 and March 2022. MRD value was calculated for both MFC and ClonoSEQ.

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